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IDENTIFICATION OF EFFECTIVE DRUGS OR DRUG COMBINATIONS TARGETING NON – STEM BREAST CANCER CELLS AND BREAST CANCER STEM CELLS

HII LING WEI (International Medical University, 2016)

Breast cancer stem cells (BCSCs), as a subset of cancer cells with enriched capacity to generate breast tumors, have recently been attributed to driving cancer recurrence and metastasis. Although the importance of developing ...
NEUROTOXIC EFFECT OF SALSOLINOL ON NE-4C NEURAL STEM CELL MEDIATED THROUGH MTOR PATHWAY

SALINI MOHAN KUMAR (International Medical University, 2019)

Parkinson’s disease is a common neurological disease characterised by motor and non-motor symptoms. Parkinson’s disease is associated with the loss of dopamine in the substantia nigra pars compacta neurons. Current treatment ...
SPHINGOSINE KINASE 1 IS A KEY REGULATOR FOR THE SURVIVAL OF HUMAN BREAST CANCER STEM CELLS VIA SUPPRESSION OF STAT1 AND INTERFERON SIGNALLING

HII LING WEI (International Medical University, 2021)

Cancer stem cells (CSCs) are a subpopulation of cancer cells with enhanced capabilities of self-renewal, differentiation and tumour initiation, and confer resistance to conventional chemotherapy. Therefore, it is important ...
THE SYNERGISTIC EFFECTS OF NANOSILVER AND NANOPROPOLIS ON ORAL MICROORGANISMS AND PERIODONTAL LIGAMENT STEM CELLS

LALLI DHARMARAJAN (International Medical University, 2019)

Intracanal medicament is an important step in reducing the microorganisms in root canals. Drug synergism occurs when two or more drugs work together to produce an effect more potent than if each drug were applied individually. ...

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