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ANTICANCER PROPERTY OF CHIRAL PAIRS OF TERNARY COPPER(II) COMPLEXES OF 1,10-PHENANTHROLINE AND ALANINE

NG PEI YING (International Medical University, 2018)

Copper complexes may serve as potential alternatives to platinum-based anticancer agents. By incorporating endogenous metal, such as copper, into metal complexes may reduce toxicity and solve other problems encountered by ...
Antiviral Activity Of Microalgae Extracts Against Epstein-Barr Virus

Kok Yih Yih (International Medical University, 2009-08)

Epstein-Barr virus (EBV) is a class I carcinogen human herpes virus which has infected 90% of humanity and most prevalent among Asians, especially Chinese. After primary infection, EBV establishes the lifelong virus carrier ...
BENZYLIDENE DERIVATIVES OF 12,13-DIHYDROANDROGRAPHOLIDE: SYNTHESIS, AND EVALUATION OF IN VITRO PHARMACOKINETICS AND NEUROPROTECTIVE PROPERTIES

TAN KHAISHIN (International Medical University, 2016)

Andrographolide (AGP) is the major ent-labdane diterpenoid isolated from Andrographis paniculata (known locally in Malaysia as Hempedu Bumi). AGP was found to exhibit neuroprotective effects by inhibiting inflammation and ...
COMPARING PROTEOMIC PROFILES OF PRIMARY PANCREATIC DUCTAL ADENOCARCINOMA CELLS (PDACs), PANCREATIC STELLATE CELLS (PSCs) AND THEIR CO-CULTURE

YEO QUIN-YIE (International Medical University, 2022)

Pancreatic ductal adenocarcinoma (PDA) has a complex tumour microenvironment (TME) that are made up of pancreatic ductal adenocarcinoma cells (PDACs) and pancreatic stellate cells (PSCs). PDACs and PSCs’ interaction allows ...
Development of In vitro and In vivo Delivery Systems for siRNA-based Therapeutics using Functionalised Single-walled Carbon Nanotubes (SWNT)

TAN YUEN FEN (International Medical University, 2018)

Carbon nanotubes (CNT) have been explored as a non-viral system for gene delivery due to their unique structure and properties. Various functionalised carbon nanotubes can act as a vehicle for the systemic delivery of ...
Effects And Mechanism Of Action Of Bacillus Thuringiensis (Bt 18) Parasporal Inclusions On Leukaemic Cell Lines (Ccrf-Sb, Ccrf-Hsb-2 And Cem-Ss) And Normal T-Lymphocytes

Chan Kok Keong (International Medical University, 2011)

Bacillus thuringiensis (Bt) parasporal proteins with anti-cancer activity have gained interest due to its selectivity towards cancer cells. This study determines the efficacy and mechanism of action of parasporal proteins ...
Effects Of Crude Carica Papaya Leaf Extract And Its Water And Methanol Fractions On Dengue Type-1 Infected Human Monocytes, Vero, C6/36 And Glial Cell Lines

Fong Yewin (International Medical University, 2013)

Dengue viruses are arthropod-borne pathogens that cause significant morbidity & mortality in many parts of the world and are often associated with explosive outbreaks. The World Health Organization estimates that about 2.5 ...
THE EFFECTS OF GERANIIN ON HUMAN BREAST CANCER CELL (MCF-7 AND MDA-MB-231) METABOLISM

DR. THENMAARAN PALANISAMY (International Medical University, 2018-08)

Geraniin, the natural polyphenolic compound extracted from the plant, Phyllanthus amarus sp, is used to study various diseases. It has been reported that geraniin possesses anti-tumour, anti-inflammatory, anti-microbial ...
EFFECTS ON B LYMPHOCYTE PROLIFERATION BY CONDITIONED MEDIA FROM PANCREATIC DUCTAL ADENOCARCINOMA AND PANCREATIC STELLATE CELLS AND CO-CULTURE OF MYELOID DERIVED SUPPRESSOR CELLS

EVELYN PRIYA A/P PETER (International Medical University, 2021)

Pancreatic ductal adenocarcinoma cells (PDACs) and pancreatic stellate cells (PSC in a concerted effort protect the tumour microenvironment from immune cells attack. However, most studies have solely focused on their ...
ELUCIDATING THE EFFECTS OF MORINGA OLEIFERA EXTRACT ON REGULATING APOPTOSIS IN HUMAN BREAST CANCER CELL LINES

FAUZIAH BINTI ABDUL MANAF (International Medical University, 2019-03)

Moringa oleifera L (Family: Moringacea) is a type of perennial angiosperm tree that consists of a few plant species. Moringa is a common vegetable used by inhabitants of tropical and sub-tropical countries. At present, M. ...
EPIGENETIC MODULATION OF TUMOUR CELL INTRINSIC IMMUNE EVASION IN PANCREATIC CANCER

CHIN SEOW FONG (International Medical University, 2021)

Background The non-immunogenic and immunosuppressive microenvironment of pancreatic ductal adenocarcinoma (PDAC) had been a major obstacle for immunotherapeutic interventions. Recent findings had shown that epigenetic ...
EVALUATION OF THE MECHANISM OF ACTION OF LACTOFERRICIN B PEPTIDE IN THE INHIBITION OF BREAST CANCER

MUHAMMAD RIZDWAN BIN MOHD ABD RAHMAN (International Medical University, 2020)

Bovine lactoferricin (Lfcin B) is a heparan sulphate-binding peptide derived from bovine milk protein lactoferrin by acid-pepsin hydrolysis. It is known for its antimicrobial and anti-cancer properties. Being a natural ...
IDENTIFICATION OF NEW MOLECULAR TARGETS FOR TREATMENT OF ENDOMETRIAL CANCER

Lim Wei Meng (International Medical University, 2019)

The current treatment strategies for endometrial cancer include chemotherapy, surgery, and radiotherapy. However, the treatment results in huge variation in response rates and adverse effects. Although the new molecularly ...
INDUCTION OF APOPTOSIS IN NORMAL CELL LINES FOLLOWING EXPOSURE TO HAIR DYE COMPONENT PARA-PHENYLENEDIAMINE

REENA A/P KASI (International Medical University, 2014)

Para-Phenylenediamine (PPD) has long been used in two-thirds of permanent oxidative hair dye formulations. Epidemiological studies and several in vitro as well as in vivo studies have showed equivocal results in potential ...
An Investigation into the Therapeutic Modulation of Aquaporin Five Expression in Salivary Gland Cells Treated with Natural Substances

Andy Goh Wei Shen (International Medical University, 2011)

Hyposalivation is an excessive, objectively determinable reduction in salivation which affects primarily menopausal women and geriatric patients above 65 years of age. Ageing per se as a cause of hyposalivation has been ...
Mechanistic Basis of Tumour Evasion from Cytotoxic T Cell (CTL) Surveillance in Pancreatic Cancer

Looi Chin King (International Medical University, 2020)

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a 5-year survival rate of less than 5%. Despite improvements in treatment strategies, the survival rate has not change over the decades, with the ...
NEUROTOXICITY OF SALSOLINOL THROUGH APOPTOSIS INDUCTION AND OXIDATIVE STRESS ON BV2 MICROGLIAL CELLS

OO JU NN (International Medical University, 2022)

Salsolinol (SAL), an endogenous neurotoxin has been identified as a potential aetiological factor in Parkinson’s disease (PD). Its neurotoxicity through apoptosis induction and oxidative stress were extensively studied in ...
PROTEOMICS ANALYSIS OF P21-ACTIVATED KINASE (PAK4) DEPLETION REVEALS NOVEL TARGETS OF PAK4 IN ORAL SQUAMOUS CELL CARCINOMA (OSCC)

TAN SI HOEY (International Medical University, 2018)

Oral squamous cell carcinoma (OSCC) accounts for 90% of all malignancies in the oral cavity and is associated with poor prognosis and survival, especially in individuals with recurrent or metastatic cancer. Thus, it is ...
Putative roles of c-Jun N-terminal kinase and downstream proteins as therapeutic molecular targets in nasopharyngeal carcinoma

CHOO HENG LUNGH (International Medical University, 2016)

Nasopharyngeal carcinoma (NPC) is the most common head and neck cancer in Southeast Asia. Despite radiotherapy being the primary treatment modality, new drugs for NPC has been slow in development. NPC has always been ...
Role Of P53 Gain-Of-Function Mutations on Epithelial-Mesenchymal Plasticity (EMP) in Immortalised Human Mammary Epithelial Cell Lines MCF-10A and MCF-12A

Yee Zong Yang (International Medical University, 2021)

Background: Mutations in the p53 gene have been observed in approximately 50% of all human cancers. In breast cancer alone, 12%-32% of luminal, 84% of basal-like and 75% of HER-2 expressing tumours have evident p53 ...

Now showing items 1-20 of 24

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