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COMPARING PROTEOMIC PROFILES OF PRIMARY PANCREATIC DUCTAL ADENOCARCINOMA CELLS (PDACs), PANCREATIC STELLATE CELLS (PSCs) AND THEIR CO-CULTURE

YEO QUIN-YIE (International Medical University, 2022)

Pancreatic ductal adenocarcinoma (PDA) has a complex tumour microenvironment (TME) that are made up of pancreatic ductal adenocarcinoma cells (PDACs) and pancreatic stellate cells (PSCs). PDACs and PSCs’ interaction allows ...
EFFECTS ON B LYMPHOCYTE PROLIFERATION BY CONDITIONED MEDIA FROM PANCREATIC DUCTAL ADENOCARCINOMA AND PANCREATIC STELLATE CELLS AND CO-CULTURE OF MYELOID DERIVED SUPPRESSOR CELLS

EVELYN PRIYA A/P PETER (International Medical University, 2021)

Pancreatic ductal adenocarcinoma cells (PDACs) and pancreatic stellate cells (PSC in a concerted effort protect the tumour microenvironment from immune cells attack. However, most studies have solely focused on their ...
EPIGENETIC MODULATION OF TUMOUR CELL INTRINSIC IMMUNE EVASION IN PANCREATIC CANCER

CHIN SEOW FONG (International Medical University, 2021)

Background The non-immunogenic and immunosuppressive microenvironment of pancreatic ductal adenocarcinoma (PDAC) had been a major obstacle for immunotherapeutic interventions. Recent findings had shown that epigenetic ...
IDENTIFICATION OF TUMOUR CELL-INTRINSIC IMMUNE MODULATORS IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC)

GAN LI LIAN (International Medical University, 2020)

Pancreatic adenocarcinoma (PDAC) ranks high among the causes of cancer-related mortality. The prognosis of this disease has not improved significantly over the past 50 years despite advancements in imaging techniques, ...
NOVEL GEMCITABINE – RE(I) TRICARBONYL COMPLEXES COMBINATIONS, CONJUGATE AND FORMULATIONS WITH LIQUID CRYSTALLINE NANOPARTICLES FOR PANCREATIC CANCER PHOTODYNAMIC THERAPY

LIEW HUI SHAN (International Medical University, 2021)

With less than 10% of the 5-year survival rate, pancreatic ductal adenocarcinoma (PDAC) is known to be one of the most lethal types of cancer. Current literature supports that gemcitabine is the first-line treatment of ...
THE ROLE OF PANCREATIC DUCTAL ADENOCARCINOMA CELLS (PDAC) AND PANCREATIC STELLATE CELLS (PSC) IN PROMOTING THE DIFFERENTIATION OF MYELOID DERIVED SUPPRESSOR CELLS (MDSC)

LING CHERN CHIANG (International Medical University, 2019)

Background Immunosuppressive microenvironment of pancreatic cancer pancreatic ductal adenocarcinoma cell (PDAC) and pancreatic stellate cell (PSC) comprise myeloid derived suppressor cells (MDSC) which greatly contribute ...

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